Description
Product Characteristics:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Synonyms: Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome prosome macropain subunit alpha type 5, Proteasome alpha5 subunit, Proteasome component 5, Proteasome subunit alpha type 5, Proteasome subunit alpha type-5, Proteasome subunit zeta, Proteasome zeta chain, PSA5_HUMAN, PSC5, PSMA5, ZETA.
Target Information: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]